ELASPIC home << Job #oncokb << P42771.G23D
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P42771.G23D

Detailed results for job #oncokb produced by ELASPIC
P42771, Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3:
G23D
1
156
Ank
HIPK4, Homeodomain-interacting protein kinase 4:
1
616
Pkinase
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Model: Wild-type | Mutant | Both
Protein: P42771 | HIPK4 | Cofactors | All
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P42771.G23D

Completed successfully

Protein, domain: P42771 Ank

Interacting with: HIPK4 Pkinase

PDB templates used: 1bi7_B, 1bi7_A

Seq identity: 0.992, 0.275 Model score: 1.161

ELASPIC ΔΔG: 0.963

ELASPIC2 (EL2) score: 0.316

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.