ELASPIC home << Job #oncokb << P42338.E1051K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P42338.E1051K

Detailed results for job #oncokb produced by ELASPIC
P42338, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform:
E1051K
1
1070
PI3_PI4_kinase
PI3K_p85B+PI3K_rbd
PI3K_C2+PI3Ka
BTK, Tyrosine-protein kinase BTK:
1
659
PH+BTK
Pkinase_Tyr
SH3_1
SH2
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Model: Wild-type | Mutant | Both
Protein: P42338 | BTK | Cofactors | All
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P42338.E1051K

Completed successfully

Protein, domain: P42338 PI3_PI4_kinase

Interacting with: BTK SH2

PDB templates used: 2y3a_A, 2y3a_B

Seq identity: 0.996, 0.294 Model score: -0.504

ELASPIC ΔΔG: -0.494

ELASPIC2 (EL2) score: -1.549

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.