ELASPIC home << Job #oncokb << P42336.G1049R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P42336.G1049R

Detailed results for job #oncokb produced by ELASPIC
P42336, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform:
G1049R
1
1068
PI3K_p85B+PI3K_rbd
PI3K_C2+PI3Ka
PI3_PI4_kinase
ATR isoform 2, Isoform 2 of Serine/threonine-protein kinase ATR:
1
2580
PI3_PI4_k..
FAT
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P42336.G1049R

Completed successfully

Protein, domain: P42336 PI3_PI4_kinase

Interacting with: ATR isoform 2 PI3_PI4_kinase

PDB templates used: 2x6f_B, 2x6f_A

Seq identity: 0.324, 0.231 Model score: 1.242

ELASPIC ΔΔG: 0.693

ELASPIC2 (EL2) score: 0.536

Mutation in databases: COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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