ELASPIC home << Job #oncokb << P42336.E453A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P42336.E453A

Detailed results for job #oncokb produced by ELASPIC
P42336, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform:
E453A
1
1068
PI3K_p85B+PI3K_rbd
PI3K_C2+PI3Ka
PI3_PI4_kinase
PIK3R3, Phosphatidylinositol 3-kinase regulatory subunit gamma:
1
461
SH2
SH2
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Model: Wild-type | Mutant | Both
Protein: P42336 | PIK3R3 | Cofactors | All
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P42336.E453A

Completed successfully

Protein, domain: P42336 PI3K_C2+PI3Ka

Interacting with: PIK3R3 SH2

PDB templates used: 4l23_A, 4l23_B

Seq identity: 0.981, 0.381 Model score: 0.137

ELASPIC ΔΔG: 2.949

ELASPIC2 (EL2) score: -1.213

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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