ELASPIC home << Job #oncokb << P40763.Y640F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P40763.Y640F

Detailed results for job #oncokb produced by ELASPIC
P40763, Signal transducer and activator of transcription 3:
Y640F
1
770
STAT_bind
SH2
STAT_int
STAT_alpha

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P40763.Y640F

Completed successfully

Protein, domain: P40763 SH2

Type: Core (stability)

PDB template used: 3cwg_A

Seq identity: 1.000 Model score: -0.440

ELASPIC ΔΔG: 0.773

ELASPIC2 (EL2) score: -2.245

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.