ELASPIC home << Job #oncokb << P40337.L158V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P40337.L158V

Detailed results for job #oncokb produced by ELASPIC
P40337, Von Hippel-Lindau disease tumor suppressor:
L158V
1
213
VHL
ELOC isoform 2, Isoform 2 of Transcription elongation factor B polypeptide 1:
1
96
Skp1_POZ
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P40337.L158V

Completed successfully

Protein, domain: P40337 VHL

Interacting with: ELOC isoform 2 Skp1_POZ

PDB templates used: 4ajy_V, 4ajy_C

Seq identity: 1.000, 0.917 Model score: -1.444

ELASPIC ΔΔG: 2.299

ELASPIC2 (EL2) score: 1.520

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.