ELASPIC home << Job #oncokb << P38398.C47G
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P38398.C47G

Detailed results for job #oncokb produced by ELASPIC
P38398, Breast cancer type 1 susceptibility protein:
C47G
1
1863
zf..
BRCT
UBE2E3, Ubiquitin-conjugating enzyme E2 E3:
1
207
UQ_con
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Model: Wild-type | Mutant | Both
Protein: P38398 | UBE2E3 | Cofactors | All
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P38398.C47G

Completed successfully

Protein, domain: P38398 zf-C3HC4

Interacting with: UBE2E3 UQ_con

PDB templates used: 3rpg_C, 3rpg_A

Seq identity: 0.347, 0.644 Model score: -0.300

ELASPIC ΔΔG: 1.643

ELASPIC2 (EL2) score: 1.485

Mutation run by user.

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Citation

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