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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P38398.C44Y

Detailed results for job #oncokb produced by ELASPIC

P38398, Breast cancer type 1 susceptibility protein:
C44Y
1
1863
A8K503, cDNA FLJ76182, highly similar to Homo sapiens ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) (UBE2I), transcript variant 1, mRNA:
1
158
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Model: Wild-type | Mutant | Both
Protein: P38398 | A8K503 | Cofactors | All
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P38398.C44Y

Completed successfully

Protein, domain: P38398 zf-C3HC4

Interacting with: A8K503 UQ_con

PDB templates used: 3rpg_C, 3rpg_A

Seq identity: 0.347, 0.357 Model score: 0.156

ELASPIC ΔΔG: 1.570

ELASPIC2 (EL2) score: 2.211

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation


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