ELASPIC home << Job #oncokb << P37173.P525L
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P37173.P525L

Detailed results for job #oncokb produced by ELASPIC
P37173, TGF-beta receptor type-2:
P525L
1
567
ecTbetaR2
Pkinase
RPS6KB1, Ribosomal protein S6 kinase beta-1:
1
525
Pkinase+Pkinase_C
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Model: Wild-type | Mutant | Both
Protein: P37173 | RPS6KB1 | Cofactors | All
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P37173.P525L

Completed successfully

Protein, domain: P37173 Pkinase

Interacting with: RPS6KB1 Pkinase+Pkinase_C

PDB templates used: 3a60_A, 3a60_B

Seq identity: 0.241, 0.885 Model score: 0.486

ELASPIC ΔΔG: 0.847

ELASPIC2 (EL2) score: 1.276

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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