ELASPIC home << Job #oncokb << P36897.S387Y
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P36897.S387Y

Detailed results for job #oncokb produced by ELASPIC
P36897, TGF-beta receptor type-1:
S387Y
1
503
Activin_recp
TGF_beta_GS+Pkinase
PIK3R1, Phosphatidylinositol 3-kinase regulatory subunit alpha:
1
724
SH3_2
SH2
RhoGAP
SH2
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Protein: P36897 | PIK3R1 | Cofactors | All
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P36897.S387Y

Completed successfully

Protein, domain: P36897 TGF_beta_GS+Pkinase

Interacting with: PIK3R1 SH2

PDB templates used: 4gl9_A, 4gl9_E

Seq identity: 0.283, 0.304 Model score: 1.253

ELASPIC ΔΔG: 1.016

ELASPIC2 (EL2) score: 0.979

Mutation run by user.

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Citation

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