ELASPIC home << Job #oncokb << P36897.S241L
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P36897.S241L

Detailed results for job #oncokb produced by ELASPIC
P36897, TGF-beta receptor type-1:
S241L
1
503
Activin_recp
TGF_beta_GS+Pkinase
EIF2AK4, Eukaryotic translation initiation factor 2-alpha kinase 4:
1
1649
RWD
Pkinase
Pkinase
Pkinase
tRNA-synt_His
Select affected interaction:
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: P36897 | EIF2AK4 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P36897.S241L

Completed successfully

Protein, domain: P36897 TGF_beta_GS+Pkinase

Interacting with: EIF2AK4 Pkinase

PDB templates used: 1zyc_B, 1zyc_A

Seq identity: 0.262, 0.443 Model score: 1.325

ELASPIC ΔΔG: 1.115

ELASPIC2 (EL2) score: 1.766

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.