ELASPIC home << Job #oncokb << P36507.S226D
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P36507.S226D

Detailed results for job #oncokb produced by ELASPIC
P36507, Dual specificity mitogen-activated protein kinase kinase 2:
S226D
1
400
Pkinase
RAF1 isoform 2, Isoform 2 of RAF proto-oncogene serine/threonine-protein kinase:
1
668
Pkinase_Tyr
RBD
C1_1
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P36507.S226D

Completed successfully

Protein, domain: P36507 Pkinase

Interacting with: RAF1 isoform 2 Pkinase_Tyr

PDB templates used: 2y4i_C, 2y4i_B

Seq identity: 0.791, 0.348 Model score: 0.156

ELASPIC ΔΔG: 2.268

ELASPIC2 (EL2) score: 1.255

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.