ELASPIC home << Job #oncokb << P31751.H355M
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P31751.H355M

Detailed results for job #oncokb produced by ELASPIC
P31751, RAC-beta serine/threonine-protein kinase:
H355M
1
481
PH
Pkinase+Pkinase_C
M3K8 isoform 2, Isoform 2 of Mitogen-activated protein kinase kinase kinase 8:
1
438
Pkinase
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P31751.H355M

Completed successfully

Protein, domain: P31751 Pkinase+Pkinase_C

Interacting with: M3K8 isoform 2 Pkinase

PDB templates used: 3a60_A, 3a60_B

Seq identity: 0.437, 0.278 Model score: 0.912

ELASPIC ΔΔG: 0.248

ELASPIC2 (EL2) score: 1.943

Mutation run by user.

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Citation

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