ELASPIC home << Job #oncokb << P31749.T195I
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P31749.T195I

Detailed results for job #oncokb produced by ELASPIC
P31749, RAC-alpha serine/threonine-protein kinase:
T195I
1
480
PH
Pkinase+Pkinase_C
GSK3B, Glycogen synthase kinase-3 beta:
1
420
Pkinase
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Model: Wild-type | Mutant | Both
Protein: P31749 | GSK3B | Cofactors | All
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P31749.T195I

Completed successfully

Protein, domain: P31749 Pkinase+Pkinase_C

Interacting with: GSK3B Pkinase

PDB templates used: 1i09_A, 1i09_B

Seq identity: 0.285, 0.986 Model score: -0.173

ELASPIC ΔΔG: 1.383

ELASPIC2 (EL2) score: 1.578

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.