ELASPIC home << Job #oncokb << P31749.L52R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P31749.L52R

Detailed results for job #oncokb produced by ELASPIC
P31749, RAC-alpha serine/threonine-protein kinase:
L52R
1
480
PH
Pkinase+Pkinase_C
RAB5A, Ras-related protein Rab-5A:
1
215
Ras
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Model: Wild-type | Mutant | Both
Protein: P31749 | RAB5A | Cofactors | All
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P31749.L52R

Completed successfully

Protein, domain: P31749 PH

Interacting with: RAB5A Ras

PDB templates used: 4kax_B, 4kax_A

Seq identity: 0.302, 0.282 Model score: -0.247

ELASPIC ΔΔG: 1.208

ELASPIC2 (EL2) score: 1.920

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.