ELASPIC home << Job #oncokb << P31749.D325A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P31749.D325A

Detailed results for job #oncokb produced by ELASPIC
P31749, RAC-alpha serine/threonine-protein kinase:
D325A
1
480
PH
Pkinase+Pkinase_C
MAP3K5, Mitogen-activated protein kinase kinase kinase 5:
1
1374
Pkinase
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Protein: P31749 | MAP3K5 | Cofactors | All
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P31749.D325A

Completed successfully

Protein, domain: P31749 Pkinase+Pkinase_C

Interacting with: MAP3K5 Pkinase

PDB templates used: 3iw4_A, 3iw4_B

Seq identity: 0.468, 0.323 Model score: 0.516

ELASPIC ΔΔG: 1.713

ELASPIC2 (EL2) score: 1.592

Mutation run by user.

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Citation

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