ELASPIC home << Job #oncokb << P31749.D323H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P31749.D323H

Detailed results for job #oncokb produced by ELASPIC
P31749, RAC-alpha serine/threonine-protein kinase:
D323H
1
480
PH
Pkinase+Pkinase_C
PPM1A, Protein phosphatase 1A:
1
382
PP2C
PP2C_C
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Model: Wild-type | Mutant | Both
Protein: P31749 | PPM1A | Cofactors | All
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P31749.D323H

Completed successfully

Protein, domain: P31749 Pkinase+Pkinase_C

Interacting with: PPM1A PP2C

PDB templates used: 3ujg_A, 3ujg_B

Seq identity: 0.340, 0.344 Model score: 0.837

ELASPIC ΔΔG: 1.420

ELASPIC2 (EL2) score: 1.173

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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