ELASPIC home << Job #oncokb << P23458.Y652H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P23458.Y652H

Detailed results for job #oncokb produced by ELASPIC
P23458, Tyrosine-protein kinase JAK1:
Y652H
1
1154
Pkinase_Tyr
Pkinase_Tyr
KCC2A isoform 2, Isoform B of Calcium/calmodulin-dependent protein kinase type II subunit alpha:
1
489
Pkinase
CaMKII_AD
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P23458.Y652H

Completed successfully

Protein, domain: P23458 Pkinase_Tyr

Interacting with: KCC2A isoform 2 Pkinase

PDB templates used: 2jam_A, 2jam_B

Seq identity: 0.281, 0.436 Model score: 0.445

ELASPIC ΔΔG: 0.331

ELASPIC2 (EL2) score: -0.414

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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