ELASPIC home << Job #oncokb << P23458.V658F
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P23458.V658F

Detailed results for job #oncokb produced by ELASPIC
P23458, Tyrosine-protein kinase JAK1:
V658F
1
1154
Pkinase_Tyr
Pkinase_Tyr
RAF1, RAF proto-oncogene serine/threonine-protein kinase:
1
648
RBD
C1_1
Pkinase_Tyr
Select affected interaction:
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: P23458 | RAF1 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P23458.V658F

Completed successfully

Protein, domain: P23458 Pkinase_Tyr

Interacting with: RAF1 Pkinase_Tyr

PDB templates used: 4l00_B, 4l00_A

Seq identity: 0.971, 0.258 Model score: -0.138

ELASPIC ΔΔG: 0.627

ELASPIC2 (EL2) score: 0.358

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.