ELASPIC home << Job #oncokb << P23458.A634D
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P23458.A634D

Detailed results for job #oncokb produced by ELASPIC
P23458, Tyrosine-protein kinase JAK1:
A634D
1
1154
Pkinase_Tyr
Pkinase_Tyr
FES isoform 3, Isoform 3 of Tyrosine-protein kinase Fes/Fps:
1
764
FCH
SH2
Pkinase_Tyr
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P23458.A634D

Completed successfully

Protein, domain: P23458 Pkinase_Tyr

Interacting with: FES isoform 3 Pkinase_Tyr

PDB templates used: 4l00_B, 4l00_A

Seq identity: 0.971, 0.289 Model score: -0.494

ELASPIC ΔΔG: 0.117

ELASPIC2 (EL2) score: 0.292

Mutation run by user.

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Citation

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