ELASPIC home << Job #oncokb << P22681.P417A
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P22681.P417A

Detailed results for job #oncokb produced by ELASPIC
P22681, E3 ubiquitin-protein ligase CBL:
P417A
1
906
zf-C3HC4
UBA
Cbl_N+Cbl_N2+Cbl_N3
UB2D2 isoform 2, Isoform 2 of Ubiquitin-conjugating enzyme E2 D2:
1
118
UQ_con
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P22681.P417A

Completed successfully

Protein, domain: P22681 zf-C3HC4

Interacting with: UB2D2 isoform 2 UQ_con

PDB templates used: 4a4c_A, 4a4c_C

Seq identity: 0.988, 0.992 Model score: -0.760

ELASPIC ΔΔG: 1.565

ELASPIC2 (EL2) score: 1.603

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.