ELASPIC home << Job #oncokb << P22681.M374V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P22681.M374V

Detailed results for job #oncokb produced by ELASPIC
P22681, E3 ubiquitin-protein ligase CBL:
M374V
1
906
zf-C3HC4
UBA
Cbl_N+Cbl_N2+Cbl_N3
UB2D3 isoform 2, Isoform 2 of Ubiquitin-conjugating enzyme E2 D3:
1
148
UQ_con
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P22681.M374V

Completed successfully

Protein, domain: P22681 zf-C3HC4

Interacting with: UB2D3 isoform 2 UQ_con

PDB templates used: 4a4c_A, 4a4c_C

Seq identity: 0.988, 0.959 Model score: -0.983

ELASPIC ΔΔG: -0.464

ELASPIC2 (EL2) score: 0.522

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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