ELASPIC home << Job #oncokb << P22681.C384R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P22681.C384R

Detailed results for job #oncokb produced by ELASPIC
P22681, E3 ubiquitin-protein ligase CBL:
C384R
1
906
zf-C3HC4
UBA
Cbl_N+Cbl_N2+Cbl_N3
UBE2M, NEDD8-conjugating enzyme Ubc12:
1
183
UQ_con
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Model: Wild-type | Mutant | Both
Protein: P22681 | UBE2M | Cofactors | All
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P22681.C384R

Completed successfully

Protein, domain: P22681 zf-C3HC4

Interacting with: UBE2M UQ_con

PDB templates used: 4a4c_A, 4a4c_C

Seq identity: 0.988, 0.357 Model score: 0.103

ELASPIC ΔΔG: 1.592

ELASPIC2 (EL2) score: 1.436

Mutation in databases: ClinVar, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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