ELASPIC home << Job #oncokb << P22607.R669G
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P22607.R669G

Detailed results for job #oncokb produced by ELASPIC
P22607, Fibroblast growth factor receptor 3:
R669G
1
806
I-set
I-set
Pkinase_Tyr
SOCS1, Suppressor of cytokine signaling 1:
1
211
SOCS_box
SH2
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Protein: P22607 | SOCS1 | Cofactors | All
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P22607.R669G

Completed successfully

Protein, domain: P22607 Pkinase_Tyr

Interacting with: SOCS1 SH2

PDB templates used: 4gl9_A, 4gl9_E

Seq identity: 0.336, 0.390 Model score: 0.229

ELASPIC ΔΔG: 1.309

ELASPIC2 (EL2) score: 0.823

Mutation run by user.

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Citation

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