ELASPIC home << Job #oncokb << P22607.G697C
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P22607.G697C

Detailed results for job #oncokb produced by ELASPIC
P22607, Fibroblast growth factor receptor 3:
G697C
1
806
I-set
I-set
Pkinase_Tyr
FGFR3 isoform 4, Isoform 4 of Fibroblast growth factor receptor 3:
1
791
I-set+I-set+ig
Pkinase_Tyr
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P22607.G697C

Completed successfully

Protein, domain: P22607 Pkinase_Tyr

Interacting with: FGFR3 isoform 4 Pkinase_Tyr

PDB templates used: 4j96_B, 4j96_A

Seq identity: 0.859, 0.822 Model score: 0.120

ELASPIC ΔΔG: 0.418

ELASPIC2 (EL2) score: 2.259

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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