ELASPIC home << Job #oncokb << P21802.R678G
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P21802.R678G

Detailed results for job #oncokb produced by ELASPIC
P21802, Fibroblast growth factor receptor 2:
R678G
1
821
I-set
I-set
Pkinase_Tyr
CDK5, Cyclin-dependent kinase 5:
1
292
Pkinase
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Model: Wild-type | Mutant | Both
Protein: P21802 | CDK5 | Cofactors | All
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P21802.R678G

Completed successfully

Protein, domain: P21802 Pkinase_Tyr

Interacting with: CDK5 Pkinase

PDB templates used: 4au8_B, 4au8_A

Seq identity: 0.272, 0.951 Model score: 0.084

ELASPIC ΔΔG: 0.425

ELASPIC2 (EL2) score: 0.377

Mutation in databases: UniProt, COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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