ELASPIC home << Job #oncokb << P21802.K659N
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P21802.K659N

Detailed results for job #oncokb produced by ELASPIC
P21802, Fibroblast growth factor receptor 2:
K659N
1
821
I-set
I-set
Pkinase_Tyr
CDK5 isoform 2, Isoform 2 of Cyclin-dependent kinase 5:
1
260
Pkinase
Pkinase
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P21802.K659N

Completed successfully

Protein, domain: P21802 Pkinase_Tyr

Interacting with: CDK5 isoform 2 Pkinase

PDB templates used: 4au8_A, 4au8_B

Seq identity: 0.263, 0.948 Model score: 0.865

ELASPIC ΔΔG: 0.515

ELASPIC2 (EL2) score: 0.939

Mutation in databases: UniProt, COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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