ELASPIC home << Job #oncokb << P21802.K526E
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P21802.K526E

Detailed results for job #oncokb produced by ELASPIC
P21802, Fibroblast growth factor receptor 2:
K526E
1
821
I-set
I-set
Pkinase_Tyr
FGFR2 isoform 4, Isoform 4 of Fibroblast growth factor receptor 2:
1
682
I-set+I-set
Pkinase_Tyr
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P21802.K526E

Completed successfully

Protein, domain: P21802 Pkinase_Tyr

Interacting with: FGFR2 isoform 4 Pkinase_Tyr

PDB templates used: 4j96_A, 4j96_B

Seq identity: 0.980, 0.993 Model score: -0.962

ELASPIC ΔΔG: 1.733

ELASPIC2 (EL2) score: 0.739

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

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