ELASPIC home << Job #oncokb << P16234.R841K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P16234.R841K

Detailed results for job #oncokb produced by ELASPIC
P16234, Platelet-derived growth factor receptor alpha:
R841K
1
1089
Pkinase_Tyr
Ig_2
I-set
GRB14, Growth factor receptor-bound protein 14:
1
540
BPS
RA+PH
SH2
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Model: Wild-type | Mutant | Both
Protein: P16234 | GRB14 | Cofactors | All
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P16234.R841K

Completed successfully

Protein, domain: P16234 Pkinase_Tyr

Interacting with: GRB14 BPS

PDB templates used: 2auh_A, 2auh_B

Seq identity: 0.408, 1.000 Model score: 0.784

ELASPIC ΔΔG: -0.847

ELASPIC2 (EL2) score: 0.889

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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