ELASPIC home << Job #oncokb << P16234.K830R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P16234.K830R

Detailed results for job #oncokb produced by ELASPIC
P16234, Platelet-derived growth factor receptor alpha:
K830R
1
1089
Pkinase_Tyr
Ig_2
I-set
SRPK1, SRSF protein kinase 1:
1
655
Pkinase
Pkinase
Select affected interaction:

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Model: Wild-type | Mutant | Both
Protein: P16234 | SRPK1 | Cofactors | All
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P16234.K830R

Completed successfully

Protein, domain: P16234 Pkinase_Tyr

Interacting with: SRPK1 Pkinase

PDB templates used: 2fys_B, 2fys_A

Seq identity: 0.328, 0.295 Model score: 1.745

ELASPIC ΔΔG: 1.083

ELASPIC2 (EL2) score: -1.538

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.