ELASPIC home << Job #oncokb << P16234.A633T
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P16234.A633T

Detailed results for job #oncokb produced by ELASPIC
P16234, Platelet-derived growth factor receptor alpha:
A633T
1
1089
Pkinase_Tyr
Ig_2
I-set
KIT isoform 2, Isoform 2 of Mast/stem cell growth factor receptor Kit:
1
972
Ig_3
Pkinase_Tyr
Ig_2
ig
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P16234.A633T

Completed successfully

Protein, domain: P16234 Pkinase_Tyr

Interacting with: KIT isoform 2 Pkinase_Tyr

PDB templates used: 4j96_A, 4j96_B

Seq identity: 0.536, 0.435 Model score: 0.744

ELASPIC ΔΔG: 0.264

ELASPIC2 (EL2) score: 1.040

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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