ELASPIC home << Job #oncokb << P15056.E586K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P15056.E586K

Detailed results for job #oncokb produced by ELASPIC
P15056, Serine/threonine-protein kinase B-raf:
E586K
1
766
RBD
C1_1
Pkinase_Tyr
KSR2, Kinase suppressor of Ras 2:
1
950
Pkinase_Tyr
KSR1-SAM
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Model: Wild-type | Mutant | Both
Protein: P15056 | KSR2 | Cofactors | All
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P15056.E586K

Completed successfully

Protein, domain: P15056 Pkinase_Tyr

Interacting with: KSR2 Pkinase_Tyr

PDB templates used: 3skc_B, 3skc_A

Seq identity: 1.000, 0.362 Model score: -0.117

ELASPIC ΔΔG: 0.062

ELASPIC2 (EL2) score: 1.115

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.