ELASPIC home << Job #oncokb << P11802.R24C
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P11802.R24C

Detailed results for job #oncokb produced by ELASPIC
P11802, Cyclin-dependent kinase 4:
R24C
1
303
Pkinase
CDKN1A, Cyclin-dependent kinase inhibitor 1:
1
164
CDI
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Model: Wild-type | Mutant | Both
Protein: P11802 | CDKN1A | Cofactors | All
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P11802.R24C

Completed successfully

Protein, domain: P11802 Pkinase

Interacting with: CDKN1A CDI

PDB templates used: 1jsu_A, 1jsu_C

Seq identity: 0.456, 0.435 Model score: -0.366

ELASPIC ΔΔG: 0.241

ELASPIC2 (EL2) score: 0.924

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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