ELASPIC home << Job #oncokb << P10721.Y823D
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P10721.Y823D

Detailed results for job #oncokb produced by ELASPIC
P10721, Mast/stem cell growth factor receptor Kit:
Y823D
1
976
Pkinase_Tyr
Ig_2
ig
Ig_3
CISH, Cytokine-inducible SH2-containing protein:
1
258
SOCS_box
SH2
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Model: Wild-type | Mutant | Both
Protein: P10721 | CISH | Cofactors | All
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P10721.Y823D

Completed successfully

Protein, domain: P10721 Pkinase_Tyr

Interacting with: CISH SH2

PDB templates used: 4gl9_A, 4gl9_E

Seq identity: 0.293, 0.393 Model score: 1.624

ELASPIC ΔΔG: 1.719

ELASPIC2 (EL2) score: 1.674

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.