ELASPIC home << Job #oncokb << P10721.V559G
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P10721.V559G

Detailed results for job #oncokb produced by ELASPIC
P10721, Mast/stem cell growth factor receptor Kit:
V559G
1
976
Pkinase_Tyr
Ig_2
ig
Ig_3
JAK3, Tyrosine-protein kinase JAK3:
1
1124
Pkinase_Tyr
Pkinase_Tyr
Select affected interaction:

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Protein: P10721 | JAK3 | Cofactors | All
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P10721.V559G

Completed successfully

Protein, domain: P10721 Pkinase_Tyr

Interacting with: JAK3 Pkinase_Tyr

PDB templates used: 4j96_B, 4j96_A

Seq identity: 0.435, 0.252 Model score: 0.758

ELASPIC ΔΔG: 1.718

ELASPIC2 (EL2) score: 0.222

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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