ELASPIC home << Job #oncokb << P07949.M918T
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P07949.M918T

Detailed results for job #oncokb produced by ELASPIC
P07949, Proto-oncogene tyrosine-protein kinase receptor Ret:
M918T
1
1114
Pkinase_Tyr
Cadhe..
GRB10 isoform 2, Isoform 1 of Growth factor receptor-bound protein 10:
1
548
RA
BPS
SH2
Select affected interaction:

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P07949.M918T

Completed successfully

Protein, domain: P07949 Pkinase_Tyr

Interacting with: GRB10 isoform 2 BPS

PDB templates used: 2auh_A, 2auh_B

Seq identity: 0.388, 0.784 Model score: -0.455

ELASPIC ΔΔG: 0.733

ELASPIC2 (EL2) score: 1.857

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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