ELASPIC home << Job #oncokb << P07949.M918T
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P07949.M918T

Detailed results for job #oncokb produced by ELASPIC
P07949, Proto-oncogene tyrosine-protein kinase receptor Ret:
M918T
1
1114
Pkinase_Tyr
Cadhe..
CRK, Adapter molecule crk:
1
304
SH3_2
SH2
SH3_1
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Model: Wild-type | Mutant | Both
Protein: P07949 | CRK | Cofactors | All
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P07949.M918T

Completed successfully

Protein, domain: P07949 Pkinase_Tyr

Interacting with: CRK SH2

PDB templates used: 4gl9_A, 4gl9_E

Seq identity: 0.333, 0.275 Model score: 0.013

ELASPIC ΔΔG: 1.311

ELASPIC2 (EL2) score: 1.706

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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