ELASPIC home << Job #oncokb << P07949.A883F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P07949.A883F

Detailed results for job #oncokb produced by ELASPIC
P07949, Proto-oncogene tyrosine-protein kinase receptor Ret:
A883F
1
1114
Pkinase_Tyr
Cadhe..
LRRK1 isoform 2, Isoform 2 of Leucine-rich repeat serine/threonine-protein kinase 1:
1
264
Ank_2
Select affected interaction:

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P07949.A883F

Completed successfully

Protein, domain: P07949 Pkinase_Tyr

Interacting with: LRRK1 isoform 2 Ank_2

PDB templates used: 1blx_A, 1blx_B

Seq identity: 0.261, 0.318 Model score: 0.314

ELASPIC ΔΔG: 2.520

ELASPIC2 (EL2) score: 0.708

Mutation in databases: ClinVar, UniProt, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.