ELASPIC home << Job #oncokb << P04637.R248L
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P04637.R248L

Detailed results for job #oncokb produced by ELASPIC
P04637, Cellular tumor antigen p53:
R248L
1
393
P53_TAD
P53+P53_tetramer
TP53, Cellular tumor antigen p53:
1
393
P53_TAD
P53+P53_tetramer
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Model: Wild-type | Mutant | Both
Protein: P04637 | TP53 | Cofactors | All
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P04637.R248L

Completed successfully

Protein, domain: P04637 P53+P53_tetramer

Interacting with: TP53 P53+P53_tetramer

PDB templates used: 4ibt_B, 4ibt_A

Seq identity: 0.990, 0.990 Model score: -0.607

ELASPIC ΔΔG: 0.368

ELASPIC2 (EL2) score: 0.579

Mutation in databases: UniProt, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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