ELASPIC home << Job #oncokb << P04637.E180K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P04637.E180K

Detailed results for job #oncokb produced by ELASPIC
P04637, Cellular tumor antigen p53:
E180K
1
393
P53_TAD
P53+P53_tetramer
NOTC4 isoform 2, Isoform 2 of Neurogenic locus notch homolog protein 4:
1
589
Ank_2+Ank_2+Ank_5
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P04637.E180K

Completed successfully

Protein, domain: P04637 P53+P53_tetramer

Interacting with: NOTC4 isoform 2 Ank_2+Ank_2+Ank_5

PDB templates used: 1ycs_A, 1ycs_B

Seq identity: 1.000, 0.348 Model score: 0.692

ELASPIC ΔΔG: 1.384

ELASPIC2 (EL2) score: 0.413

Mutation in databases: UniProt, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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