ELASPIC home << Job #oncokb << P04626.V794M
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P04626.V794M

Detailed results for job #oncokb produced by ELASPIC
P04626, Receptor tyrosine-protein kinase erbB-2:
V794M
1
1255
Recep_L_..
Pkinase_Tyr
Furin-like
GF_rec..
Recep_L_..
ABL2 isoform 10, Isoform 10 of Abelson tyrosine-protein kinase 2:
1
1064
F_act..
Pkinase_Tyr
SH..
SH2
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P04626.V794M

Completed successfully

Protein, domain: P04626 Pkinase_Tyr

Interacting with: ABL2 isoform 10 Pkinase_Tyr

PDB templates used: 3pp0_A, 3pp0_B

Seq identity: 0.986, 0.427 Model score: -0.670

ELASPIC ΔΔG: 0.418

ELASPIC2 (EL2) score: -1.501

Mutation run by user.

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Citation

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