ELASPIC home << Job #oncokb << P04626.S310F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P04626.S310F

Detailed results for job #oncokb produced by ELASPIC
P04626, Receptor tyrosine-protein kinase erbB-2:
S310F
1
1255
Recep_L_..
Pkinase_Tyr
Furin-like
GF_rec..
Recep_L_..
EGFR, Epidermal growth factor receptor:
1
1210
Recep_L_d..
Recep_..
Furin..
Pkinase_Tyr
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Model: Wild-type | Mutant | Both
Protein: P04626 | EGFR | Cofactors | All
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P04626.S310F

Completed successfully

Protein, domain: P04626 Furin-like

Interacting with: EGFR Furin-like

PDB templates used: 1mox_A, 1mox_B

Seq identity: 0.490, 1.000 Model score: 0.900

ELASPIC ΔΔG: 1.392

ELASPIC2 (EL2) score: 0.789

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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