ELASPIC home << Job #oncokb << P04626.L866M
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P04626.L866M

Detailed results for job #oncokb produced by ELASPIC
P04626, Receptor tyrosine-protein kinase erbB-2:
L866M
1
1255
Recep_L_..
Pkinase_Tyr
Furin-like
GF_rec..
Recep_L_..
PAK1 isoform 2, Isoform 2 of Serine/threonine-protein kinase PAK 1:
1
553
PBD
Pkinase
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P04626.L866M

Completed successfully

Protein, domain: P04626 Pkinase_Tyr

Interacting with: PAK1 isoform 2 PBD

PDB templates used: 1f3m_D, 1f3m_B

Seq identity: 0.259, 1.000 Model score: 0.248

ELASPIC ΔΔG: -0.218

ELASPIC2 (EL2) score: 1.943

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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