ELASPIC home << Job #oncokb << P04626.E719K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P04626.E719K

Detailed results for job #oncokb produced by ELASPIC
P04626, Receptor tyrosine-protein kinase erbB-2:
E719K
1
1255
Recep_L_..
Pkinase_Tyr
Furin-like
GF_rec..
Recep_L_..
TGFR1 isoform 3, Isoform 3 of TGF-beta receptor type-1:
1
426
Activin_recp
TGF_beta_GS+Pkinase
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P04626.E719K

Completed successfully

Protein, domain: P04626 Pkinase_Tyr

Interacting with: TGFR1 isoform 3 TGF_beta_GS+Pkinase

PDB templates used: 3pp0_A, 3pp0_B

Seq identity: 0.986, 0.264 Model score: -0.284

ELASPIC ΔΔG: 0.590

ELASPIC2 (EL2) score: 2.055

Mutation run by user.

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Citation

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