ELASPIC home << Job #oncokb << P04049.I448V
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P04049.I448V

Detailed results for job #oncokb produced by ELASPIC
P04049, RAF proto-oncogene serine/threonine-protein kinase:
I448V
1
648
RBD
C1_1
Pkinase_Tyr
MK07 isoform 2, Isoform 2 of Mitogen-activated protein kinase 7:
1
677
Pkinase
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P04049.I448V

Completed successfully

Protein, domain: P04049 Pkinase_Tyr

Interacting with: MK07 isoform 2 Pkinase

PDB templates used: 4ic8_B, 4ic8_A

Seq identity: 0.261, 0.916 Model score: 1.428

ELASPIC ΔΔG: -0.381

ELASPIC2 (EL2) score: 0.917

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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