ELASPIC home << Job #oncokb << P03372.S463P
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P03372.S463P

Detailed results for job #oncokb produced by ELASPIC
P03372, Estrogen receptor:
S463P
1
595
zf-C4+Hormone_recep
NR1H4, Bile acid receptor:
1
486
zf-C4+Hormone_recep
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: P03372 | NR1H4 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P03372.S463P

Completed successfully

Protein, domain: P03372 zf-C4+Hormone_recep

Interacting with: NR1H4 zf-C4+Hormone_recep

PDB templates used: 2qa8_B, 2qa8_A

Seq identity: 0.951, 0.246 Model score: 0.025

ELASPIC ΔΔG: 1.982

ELASPIC2 (EL2) score: -0.408

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.