ELASPIC home << Job #oncokb << P01116.D33E
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P01116.D33E

Detailed results for job #oncokb produced by ELASPIC
P01116, GTPase KRas:
D33E
1
189
Ras
RASF5 isoform 3, Isoform 3 of Ras association domain-containing protein 5:
1
336
RA
C1_1
Select affected interaction:

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P01116.D33E

Completed successfully

Protein, domain: P01116 Ras

Interacting with: RASF5 isoform 3 RA

PDB templates used: 3ddc_A, 3ddc_B

Seq identity: 0.928, 0.762 Model score: -0.385

ELASPIC ΔΔG: 3.191

ELASPIC2 (EL2) score: 1.922

Mutation in databases: COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.