ELASPIC home << Job #oncokb << P01112.A59G
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P01112.A59G

Detailed results for job #oncokb produced by ELASPIC
P01112, GTPase HRas:
A59G
1
189
Ras
VAV1, Proto-oncogene vav:
1
845
CH
RhoGEF
PH
C1_1
SH2
SH3_1
SH3_1
Select affected interaction:

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Model: Wild-type | Mutant | Both
Protein: P01112 | VAV1 | Cofactors | All
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P01112.A59G

Completed successfully

Protein, domain: P01112 Ras

Interacting with: VAV1 RhoGEF

PDB templates used: 3bji_D, 3bji_A

Seq identity: 0.316, 1.000 Model score: -1.103

ELASPIC ΔΔG: 0.052

ELASPIC2 (EL2) score: 2.565

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.