ELASPIC home << Job #oncokb << P01111.G13D
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P01111.G13D

Detailed results for job #oncokb produced by ELASPIC
P01111, GTPase NRas:
G13D
1
189
Ras
AFAD isoform 2, Isoform 1 of Afadin:
1
1612
DIL
PDZ
FHA
Select affected interaction:

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P01111.G13D

Completed successfully

Protein, domain: P01111 Ras

Interacting with: AFAD isoform 2 DIL

PDB templates used: 4lx0_C, 4lx0_D

Seq identity: 0.383, 0.222 Model score: 1.081

ELASPIC ΔΔG: 0.518

ELASPIC2 (EL2) score: 2.589

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.