ELASPIC home << Job #oncokb << P00533.L858M
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00533.L858M

Detailed results for job #oncokb produced by ELASPIC
P00533, Epidermal growth factor receptor:
L858M
1
1210
Recep_L_d..
Recep_..
Furin..
Pkinase_Tyr
GRB10, Growth factor receptor-bound protein 10:
1
594
BPS
RA+PH
SH2
Select affected interaction:

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Model: Wild-type | Mutant | Both
Protein: P00533 | GRB10 | Cofactors | All
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P00533.L858M

Completed successfully

Protein, domain: P00533 Pkinase_Tyr

Interacting with: GRB10 BPS

PDB templates used: 2auh_A, 2auh_B

Seq identity: 0.362, 0.784 Model score: -0.183

ELASPIC ΔΔG: -0.395

ELASPIC2 (EL2) score: 1.696

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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